重组人生长激素治疗失代偿性肝硬化临床研究

目的探讨重组人生长激素(r-hGH)治疗失代偿性肝硬化的临床疗效.方法 60例失代偿性肝硬化患者,随机分为两组:对照组给予常规保肝及对症治疗;治疗组在此基础上给予r-hGH 4IU,皮下注射,1次/d,连续10 d.观察血清白蛋白、球蛋白、胆红素、丙氨酸氨基转移酶、凝血酶原时间、层粘连蛋白、透明质酸、血糖及血常规等;同时记录症状及体征改善情况.结果疗程结束后治疗组患者一般状况较前明显好转;血清层粘连蛋白和透明质酸明显降低(P＜0.05);肝功能明显改善(P＜0.05).血糖、血常规无明显改变.结论r-hGH具有一定程度的抗肝纤维化、改善肝功能作用,无明显不良反应.

Clinical effects of recombinant human growth hormone in patients with decompensated liver cirrhosis

Objective To study the clinical effects of recombinant human g rowth hormone (r-hGH) on treatment of decompensated liver cirrhosis patients. Methods 60 patients were randomly divided into tow groups: Treated group, give n r-hGH in a dose of 4 IU per day subcutaneously for 10 days on the basis of rou tine therapy; Control group, routine therapy of liver protection and anti-sympto matic measures were only scheduled. The serum level of albumin, globulin, total bilirubin, alanine aminotransferase, laminin, hyaluronic acid and blood sugar as well as prothrombin time and changes of blood routine were measured before and after treatment. The clinical symptoms and signs were recorded. Results Afte r being treated for 10 days, the subjective status of treated group patients imp roved; The level of albumin in Treated group increased, significantly higher tha n that before treatment (P<0.01) and also higher than that in control group (P<0 .05), and the levels of globulin, total bilirubin, alanine aminotransferase, lam inin and hyaluronic acid decreased, respectively, markedly lower than those befo re treatment (P<0.01) and also lower than those in control group (P<0.05); Chang es of blood sugar and blood routine were not observed in tow groups; No side eff ects were reported. Conclusion r-hGH has certain effects of anti-fibrosis an d enhancing liver function and no any adverse effect is observed.