基质金属蛋白酶作为牙周炎调节因子的研究进展

牙周炎是一种感染性疾病，与微生物、宿主和环境有关，通过免疫性破坏牙周支持组织导致牙齿脱落。基质金属蛋白酶(MMPs)在牙周组织的破坏过程中起到关键作用。在蛋白酶网络中，MMPs的功能对于包括免疫、炎症、骨吸收和伤口愈合的许多生理和病理过程是至关重要的。研究指出MMPs在牙周炎激活级联中聚集，除了它们的经典底物细胞外基质之外，它们还能裂解一些信号分子，如细胞因子、趋化因子和生长因子，在牙周病中调节它们的生物功能和/或生物可得性。本文概述了MMPs作为牙周炎症调节因子的有力证据。

Research progress of matrix metalloproteinases as modulators of periodontitis

Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss which is associated with microorganisms, host and environment.Matrix metalloproteinasas are key proteases involved in destructive periodontal diseases.The huge complexity of MMP functions within the protease web is crucial for many physiologic pathologic processes ,including immunity inflammation ,bone resorption,and wound healing .Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates ,they cleave several signalling molecules -such as cytokines,chemokines,and growth factors ,among others-regulating their biological functions and /or bioavailability during periodontal disease.In this review,we provide a strong evidence that MMPs serve as regulators of periodontal inflammation.