牙周基础治疗调节2型糖尿病患者代谢的研究进展

牙周炎与糖尿病密切相关，糖尿病是牙周炎的全身促进因素之一，牙周炎会加重糖尿病的病情和代谢紊乱程度。牙周基础治疗在这个双向关系中意义重大，能显著改善牙周支持组织状态、降低血清和龈沟液中炎症因子的表达，研究发现这与牙龈卟啉单胞菌fimA II型减少和内皮祖细胞免疫炎症基因等体内相关炎症基因表达降低有关。一些研究还表明牙周基础治疗能减少胰岛素拮抗脂肪因子释放、增加胰岛素敏感脂肪因子生成，缓解胰岛素抵抗；或因加强脂肪组织代谢相关基因和炎症标志物基因的表达，而对患者的糖脂代谢有益。因此，明确牙周基础治疗对2型糖尿病伴牙周炎患者的影响及相关机制，可为防治2型糖尿病及其并发症提供新的理论依据。

Research progress on the metabolism of patients with type 2 diabetes mellitus via periodontal non-surgical treatment

Periodontitis is closely related to diabetes. Diabetes is one of the systemic stimulants of periodontitis, and Periodontitis can aggravate the severity of diabetes and the status of metabolic disorders. Periodontal non-surgical treatment(PNT) is of great significance in this bi-directional relationship. It can significantly improve the state of periodontal support tissue , reduce the expression of inflammatory factors in serum and gingival crevicular fluid，which was found that these in connection with a notable reduction of type II fimA of porphyromonas gingivalis and the suppression of related inflammatory genes, such as immuno-inflammatory gene in endothelial progenitor cells. Studies have shown that PNT can alleviate insulin resistance by reducing the release of insulin-antagonizing adipokines and increasing the production of insulin-sensitizing adipokines, and may also benefit glucose and lipid metabolism by improving the expression of metabolism and inflammation-related genes in fat tissue. Identifying the effect and related mechanisms of PNT on type 2 diabetes mellitus with chronic periodontitis patients could provide new theoretical evidence for the prevention and therapy of type 2 diabetes mellitus and complications.