黄连素及黄连的不良反应

黄连(Coptis Chinensis Franch)系毛茛科,黄连属的多年生草本植物的根茎,主要成分为小檗碱,又称黄连素(Berberine)。中医以黄连入药,主要用于烦热神昏,心烦失眠,湿热痞满,呕吐,腹痛泻痢,目赤肿毒,口舌生疮,湿疹,烫伤,吐血,衄血等。因黄连素与黄连具有较强的抗菌、抗病毒、抗原虫、利胆、止血等作用,故西医用于治疗肠炎、细菌性痢疾、阿米巴痢疾、上呼吸道感染、结核病、慢性肝炎、慢性胆囊炎、外科各

Side Effects of Coptis Chinensis and Berberine

Berberine is the main component of Coptis Chinensis Franch.Both Coptis and Berberine have been widely used in clinical practice today.Their side effects are described below: Administration of either Coptis or Berberine may cause drug rash,dizziness,palpitation,hard breathing. spasm,arthrodynia and numbness in tongue.Furthermore,administration of Coptis may cause nausea,vomiting, enterocinetic sound,abdominal distension,diarrhoea,polyuria and erythropenia,whereas administration of Berberine may cause tinnitus,anaphylactic shock,arrhythmia,frequent extrasystole and Adams-Stokes syndrome. Experiments on animals showed that a large dose of Berberine given intravenously caused drop of blood pressure. stop of heartbeat,temporary breathlessness,erythropenia,neutropenia,eosinopenia,ly phocytosis,monocytosis. contraction of granulations of erythrocyte and leucocyte,and the strengthening of the function of leucocyte phagocytosis. The side effects from the use of Berberine are more serious than those from the use of Coptis,and compared with oral administration,intravenous drop injection produces more serious side effects.Therefore,Coptis and Berberine tend to produce more serious side effects in those patients with anaphylactic history.