血清胱蛋白酶抑制剂C评估原发性高血压病肾功能检测的临床意义

目的:评价血清胱蛋白酶抑制剂C(CysC)在原发性高血压肾功能损害诊断中的临床价值。方法:80例不同程度肾功能患者及30例健康体检者分别测定尿微量蛋白定量、血尿酸、血清CysC、血肌酐值并进行比较。结果:血清CysC在GFR40～80mL/(min·1.73m2)开始明显升高,尿微量蛋白定量、血尿酸的测定在GFR正常时已经开始升高。结论:血清CysC对评价原发性高血压病肾功能损害中较血肌酐更敏感,但不比尿微量蛋白定量、血尿酸对早期原发性高血压肾损害灵敏。

Significance of serum cystatin C as a new marker for evaluating renal function in essential hypertension

Objective To evaluate the value of serum cystatin C in the diagnos is of renal impairment in patients with essential hypertension. Methods Urinary albumin excretion rate (UAER), serum uric acid, serum Cys C and serum creatinime level were measured in 80 patients with all kinds of renal impairment. And 30 h ealthy donors were similarly examined in control group. Results In GFR 40～80 mL /(min·1.73 m2) patients, The level of serum Cys C were increased greatly than s erum creatinime(P< 0.001), But in GFR >80 mL...