| 基质细胞衍生因子-1/CXCR4轴与肝脏疾病 |
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| 引用本文： | 牟晓洋,周浩锋,雷正明. 基质细胞衍生因子-1/CXCR4轴与肝脏疾病[J]. 世界华人消化杂志, 2007, 15(27): 2891-2896 |
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| 作者姓名： | 牟晓洋 周浩锋 雷正明 |
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| 作者单位： | 泸州医学院附属医院肝胆外科,四川省泸州市,646000;泸州医学院附属医院肝胆外科,四川省泸州市,646000;泸州医学院附属医院肝胆外科,四川省泸州市,646000 |
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| 摘 要： | 基质细胞衍生因子-1(SDF-1)/CXCR4轴及其介导的细胞信号转导通路在肝脏疾病中的作用是国内外研究的热点.研究发现SDF-1/ CXCR4信号转导途径与肝脏再生、炎症、肝硬化以及肿瘤等疾病有关,但其具体机制尚未完全清楚.在细胞微环境中,SDF-1/CXCR4相互作用促进肝癌细胞生长,增强肿瘤的迁移、浸润以及转移能力.本文就SDF-1/CXCR4通路在肝再生、炎症、肿瘤疾病中的病理特征和致病机制的研究进展作一综述.
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| 关 键 词： | 基质细胞衍生因子-1/SDF-1 CXCR4 肝脏疾病 转移 |
| 收稿时间： | 2007-08-03 |
| 修稿时间： | 2007-09-11 |
Relationship between stromal cell-derived factor-1/CXC chemokine receptor 4 axis and liver disease |
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| Xiao-Yang Mou,Hao-Feng Zhou,Zheng-Ming Lei. Relationship between stromal cell-derived factor-1/CXC chemokine receptor 4 axis and liver disease[J]. World Chinese Journal of Digestology, 2007, 15(27): 2891-2896 |
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| Authors: | Xiao-Yang Mou Hao-Feng Zhou Zheng-Ming Lei |
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| Abstract: | The chemokine stromal-derived factor-1 (SDF-1)and CXC chemokine receptor 4 (CXCR4)axis,and its signaling transduction pathway in liver diseases,have been the focus of intense investigation worldwide.It has been demonstrated that the SDF-1/CXCR4 signaling pathway has implications for many liver diseases, including hepatic regeneration,hepatitis,cirrhosis, and liver tumor,but the exact mechanism remain unclear.Furthermore,the interaction of SDF-1 and CXCR4 promotes hepatoma cell growth, enhances tumor migration and invasion,and contributes to tumor metastasis within the tumor microenvironment.In this review,we consider the pathological characteristics and mechanism of the SDF-1/CXCR4 pathway in hepatic regeneration, hepatitis and liver tumors. |
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| Keywords: | Stromal cell-derived factor-1 CXC chemokine receptor 4 Liver diseases Metastasis |
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