WWOX在宫颈鳞癌的表达及其与Bcl-2的相关性

目的研究WWOX、Bcl-2在宫颈鳞癌、癌旁组织及正常宫颈粘膜中的表达及两者之间的关系。方法应用免疫组织化学S-P法,检测WWOX、Bcl-2在60例宫颈鳞状细胞癌组织、20例癌旁组织和20例正常宫颈粘膜中的表达情况。结果WWOX在宫颈鳞癌中蛋白阳性表达为43.3%,明显低于癌旁正常宫颈粘膜组织（75%）和正常宫颈粘膜（100%）;Bcl-2在宫颈鳞癌中蛋白阳性表达为68.3%,明显高于癌旁正常宫颈粘膜组织（35%）和正常宫颈粘膜（25%）。WWOX和Bcl-2的阳性表达在不同病理分级及病理分期之间有差异（P〈0.01）,两者表达具有相关性（P〈0.01）,WWOX的阳性表达与淋巴结有无转移有关（P〈0.05）,Bcl-2的阳性表达与淋巴结有无转移无关（P〉0.05）。结论WWOX和Bcl-2的表达与宫颈鳞癌发生、临床进展及预后密切相关,二者在宫颈鳞癌中起相互拮抗作用。

Expression of WWOX and its ccorrelation with Bcl-2 in cervix squamous cell carcinoma

Objective:To discuss the representation and significance of WWOX,Bcl-2 in cervix squamous cell carcinoma,adjacent cervical mucosa and normal cervical mucosa.Methods:The representation of WWOX,Bcl-2 in the 20 cases of normal cervical mucosa,20 cases of adjacent cervical mucosa and 60 cases of cervix squamous cell carcinoma were checked by immunohistochemistry SP method.Results:The representation of WWOX was lower in cervix squamous cell carcinoma than that in adjacent cervical mucosa and normal cervical mucosa(P<0.01).The representation of Bcl-2 was higher in cervix squamous cell carcinoma than that in adjacent cervical mucosa and normal cervical mucosa(P<0.01).The representations of WWOX and Bcl-2 were related to the pathological grade and the pathological stage(P<0.01).The expression of WWOX was significantly related to that of Bcl-2(P<0.01).The representation of WWOX was closely related to lymphatic metastasis(P<0.05),but that of Bcl-2 was not so(P>0.05).Conclusion:The positive stainings of WWOX and Bcl-2 are related to the carcinogenesis,progression and prognosis of cervix squamous cell carcinoma,and they resist each other in cervix squamous cell carcinoma.