| 吡格列酮对胰岛素抵抗细胞糖代谢糖异生的影响 |
| |
| 引用本文： | 韩坤,李德恒,袁磊.吡格列酮对胰岛素抵抗细胞糖代谢糖异生的影响[J].四川生理科学杂志,2010,32(2):73-74. |
| |
| 作者姓名： | 韩坤 李德恒 袁磊 |
| |
| 作者单位： | 漯河医学高等专科学校生理教研室,河南,漯河,462002 |
| |
| 摘 要： | 目的：研究吡格列酮对胰岛素抵抗细胞糖代谢糖异生的影响。方法：采用地塞米松诱导3T3-L1脂肪细胞复制胰岛素抵抗模型，观察吡格列酮对胰岛素抵抗细胞葡萄糖消耗、糖异生的影响。结果：吡格列酮能显著增加胰岛素抵抗细胞的葡萄糖消耗，并且与胰岛素有协同抑制胰岛素抵抗3T3-L1脂肪细胞糖并生的作用。结论：吡格列酮可通过抑制糖异生途径改善胰岛素抵抗细胞的糖代谢。
|
| 关 键 词： | 3T3-L1脂肪细胞 胰岛素抵抗 糖代谢 糖异生 |
Effect of pioglitazone on glymetabolism and glyconeogenesis in insulin resistance cells |
| |
| Han kun,Li De-heng,Yuan Lei.Effect of pioglitazone on glymetabolism and glyconeogenesis in insulin resistance cells[J].Sichuan Journal of Physiological Sciences,2010,32(2):73-74. |
| |
| Authors: | Han kun Li De-heng Yuan Lei |
| |
| Institution: | (Department of Physiology, Luohe Medical Colloge, Henan Luohe 462002) |
| |
| Abstract: | Objective： To investigate the effect of Pioglitazone on glymetabolism and glyconeogenesis with insulin resistance ceils. Methods： To observe the impact of Pioglitazone on glymetabolism and glyeoneogenesis with insulin-resistant 3T3-L1 adipoeytes cell model. Results： Pioglitazone significantly increased the consumption of glucose in insulin resistance cells, and the repression of glyconeogenesis by Pioglitazone in 3T3-L1 adipoeytes cell can supported by the addition of insulin. Conclusion： Pioglitazone improve the glymetabolism through the glyconeogenesis pathway in insulin resistance cells . |
| |
| Keywords: | 3T3-L1 adipocytes Isulin resistant Glymetabolism Glyconeogenesis |
| 本文献已被 维普 万方数据 等数据库收录！ |
