宫颈环形电切除术后保妇康栓治疗人乳头瘤病毒阳性宫颈糜烂

目的：观察宫颈环形电切除术（LEEP）后采用保妇康栓治疗人乳头瘤病毒（HPV）阳性宫颈糜烂的疗效。方法：168例HPV阳性宫颈糜烂患者分为观察组和对照组。两组患者均行LEEP术治疗,术后常规予重组人干扰素α2a注射液300万IU,im qd。对照组术后1个月后予复方沙棘籽油栓2.7 g qd阴道给药,观察组术后1个月后予保妇康栓3.48 g qd阴道给药。疗程均为2周。观察两组患者各项症状改善情况,HPV DNA负荷量及转阴率,比较两组疗效。结果：治疗后,两组患者白带异常、腰骶疼痛、下腹胀痛及接触性出血等临床症状均得到明显改善（P〈0.01）,且观察组症状改善状况明显优于对照组（P〈0.01）。两组患者的HPV DNA负荷量均明显降低（P〈0.01）,且观察组治疗后负荷量明显低于对照组（P〈0.01）,HPV转阴率明显高于对照组（P〈0.01）。观察组总有效率（95.45%）明显高于对照组（P〈0.01）。结论：LEEP后采用保妇康栓治疗HPV阳性宫颈糜烂疗效显著,能明显改善患者各项症状,降低HPV DNA负荷量,提高HPV转阴率。

Efficacy of Baofukang Suppository after LEEP in Patients with HPV positive Cervical Erosion

Objective：To study the efficacy of Baofukang suppository after LEEP（ Loop Electrosurgical Excision Procedure） in the patients with Human papillomavirus （HPV） -positive cervical erosion. Methods： 168 cases of patients with HPV-positive cervical erosion were randomly divided into observation group and control group. Two groups were treated with LEEP surgery and were given IFN ct2a 3 million IU, im qd. One month after the surgery, the control group were treated with Seabuckthorn seed oil suppository, and the observation group were treated with Baofukang suppository. After 2 weeks treatment , the improvement of symptoms , HPV DNA load and negative rate of the two groups were recorded, and response evaluation criteria were used to assesse the efficacy of two,groups. Results： After treatment , abnormal vaginal discharge , lumbosacral pain, abdominal pain and contact bleeding symptoms of the two groups were significantly improved （P 〈 0.01 ）. In addition, the improvement of symptoms in observation group was greater than control group（P 〈 0.01 ）. HPV DNA load of the two groups were significantly lower（ P 〈 0. 01 ）. The observation group had lower load than control group（ P 〈0.01 ）. HPV negatiye rate in observation group was significantly higher than the rate of control grouo . The two groups was statistically significant（P 〈0.01 ）. The total treatment efficiency（95.45% ） of the observation group was significantly higher than the control group （P 〈 0.01）. Conclusion：The efficacy of B aofukang suppository in the patients with HPV -pos- itive cervical erosion is significant, and worthy of clinical application .