| 尿酸与脑梗死关系的研究进展 |
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| 引用本文： | 李递通,梁志坚.尿酸与脑梗死关系的研究进展[J].医学综述,2013,19(4):612-614. |
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| 作者姓名： | 李递通 梁志坚 |
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| 作者单位： | 广西玉林市第二人民医院神经内科;广西医科大学第一附属医院神经内科 |
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| 摘 要： | 尿酸是一种水溶性抗氧化剂、强大的氧自由基清除剂,动物实验表明血中高尿酸水平对缺血的脑组织有保护作用。然而,临床上关于尿酸与脑梗死的关系却颇有争议。一方面,传统的研究表明高尿酸血症常与高血压、血脂异常等同时存在,可能会增加患者发生脑梗死的风险,并使其预后不良;另一方面,新近的研究显示,高尿酸血症对脑梗死患者梗死灶周围缺血性脑组织的超氧化损伤有保护作用。
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| 关 键 词： | 尿酸 缺血性 脑血管病 |
Advances in the Research of the Relationship between Uric Acid and Cerebral Infarction |
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| LI Di-tong,LIANG Zhi-jian.Advances in the Research of the Relationship between Uric Acid and Cerebral Infarction[J].Medical Recapitulate,2013,19(4):612-614. |
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| Authors: | LI Di-tong LIANG Zhi-jian |
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| Institution: | 1.Department of Neurology,Yulin Seconde People′s Hospital,Yulin 537000,China;2.Department of Neurology,Guangxi Medical University First Affiliated Hospital,Nanning 530021,China) |
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| Abstract: | Uric acid is a water-soluble antioxidant,also a powerful free radical scavenger.Study with experimental cerebral ischemia has demonstrated the neuroprotective effects of elevated serum uric acid.But in clinical,the relationship between uric acid and cerebral infarction is controverted.Traditional research demonstrated that hyperuricemia always coexists with hypertension and dyslipidemia,which will lead to a poor prognosis for cerebral infarction;however recent clinical study demonstrated the neuroprotective effects of elevated serum uric acid,because uric acid could scavenge superoxide that mediated oxidative damage in the brain tissues around infarction. |
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| Keywords: | Uric acid Ischemic Cerebrovascular disease |
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