血清尿酸浓度与缺血性脑卒中关系的研究进展

大量研究报道升高的血清尿酸浓度与缺血性脑卒中(IS)发病、死亡和脑卒中后神经功能缺损有关,可能是缺血性脑卒中的独立危险因子。另有报道尿酸作为血管内最主要的抗氧化剂,在IS急性期氧化应激过程中可能起抗氧化作用,但当血清总体抗氧化能力较低时却起促氧化作用。而动物实验证据提示外源性尿酸干预与阿替普酶联合治疗可能增加急性IS溶栓治疗临床获益。目前血清尿酸浓度与IS之间的关系仍存争议。

Research Progress of the Relationship between Serum Uric Acid Level and Ischemic Stroke

A wealth of prospective and epidemiological evidence have identified an association between elevated serum uric acid level and morbidity,mortality and neurologic impairment related to stroke,while some have reported that elevated serum uric acid may be an independent risk factor of stroke.In addition,uric acid as the most important endogenous antioxidant in human,it may play a role in the protection against oxidative stress in acute ischemic stroke.Elevated serum uric acid may accelerate the oxidative stress in the lower total antioxidant activity of plasma.Recently,the animal experiment evidence have supported that the dual administration of exogenous UA and rt-PA may increase the clinical effect of rt-PA thrombolytic therapy.So far,the relationship between elevated serum uric acid and acute ischemic stroke is still controversial.