| Rho/Rho激酶信号通路与中枢神经系统炎性脱髓鞘病 |
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| 引用本文： | 皇甫蓓蓓,仝兆锋,曹秉振. Rho/Rho激酶信号通路与中枢神经系统炎性脱髓鞘病[J]. 医学综述, 2013, 19(4): 615-617 |
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| 作者姓名： | 皇甫蓓蓓 仝兆锋 曹秉振 |
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| 作者单位： | 菏泽市疾病预防控制中心结防科;菏泽市牡丹人民医院神经外科;济南军区总医院神经内科 |
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| 摘 要： | Rho/Rho激酶信号通路是各组织细胞中普通存在的一条信号通路,通过激酶级联反应调节细胞内微丝骨架的聚合状态,参与细胞多种生物学行为。Rho/Rho激酶信号通路在中枢神经系统(CNS)炎性脱髓鞘病的发病机制中发挥了重要作用,抑制Rho/Rho激酶信号通路可起到神经保护作用。该文就该信号通路的生物学特征及其在CNS炎性脱髓鞘病中作用的研究进展予以综述。
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| 关 键 词： | Rho激酶 多发性硬化 实验性变态反应性脑脊髓炎 Rho/Rho激酶抑制剂 神经保护 |
Rho/Rho-kinase Signaling Pathways and CNS Inflammatory Demyelinating Disease |
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| HUANG-FU Bei-bei,TONG Zhao-feng,CAO Bing-zhen. Rho/Rho-kinase Signaling Pathways and CNS Inflammatory Demyelinating Disease[J]. Medical Recapitulate, 2013, 19(4): 615-617 |
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| Authors: | HUANG-FU Bei-bei TONG Zhao-feng CAO Bing-zhen |
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| Affiliation: | 1.Heze Center for Disease Control,Heze 274000,China;2.Department of Neurosurgery,Heze Peony People′s Hospital,Heze 274000,China;3.Department of Neurology,Jinan General Military Hospital,Jinan 250031,China) |
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| Abstract: | Rho/Rho-kinase are ubiquitously expressed proteins in intracelluar signal transduction pathways.Rho/Rho-kinase signalling pathways participate in diverse cellular biological behaviors through kinase cascades regulating polymerization of microfilament cytoskeleton in cell.Rho/Rho-kinase pathway plays an important role in central nervous system(CNS) inflammatory demyelinating disease in pathogenesis.Inhibition of Rho/Rho-kinase signalling pathways leads to a neuroprotective effect.Here is to make a review on the advances in the study of the biological characteristics of the signaling pathway and its role in CNS inflammatory demyelinating disease. |
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| Keywords: | Rho-kinase Multiple sclerosis Experimental allergic encephalomyelitis Rho/Rho kinase inhibitors Neural protection |
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