去甲氧柔红霉素在急性白血病中的应用

去甲氧柔红霉素(IDA)是临床上常用的蒽环类抗肿瘤药物,与其他传统葱环类药物相比,IDA具有不良反应小、耐药程度低、抗白血病作用更强等优点。IDA与阿糖胞苷组成的IA(IDA+Ara-c)方案已成为急性髓系白血病诱导缓解的一线方案,同时使用IDA增强恶性血液系统疾病移植前预处理强度,能降低移植后复发率,提高长期无病存活率。

Clinical Application of Idarubicin in Acute Leukemia

Idarubicin(IDA) is a anthracycline anticancer drug commonly used in clinical.IDA has fewer adverse reactions,lower level of resistance and greater antileukemic activity compared with other conventional anthracycline drugs.The IA program consisting of IDA and Ara-c has become the first-line induction and remission solution in acute myeloid leukemia(AML).IDA intensifying the strength of pretreatment prior to transplantation of hematological malignancies can decrease relapse and improve the long-term disease-free survival.