| 正畸牙齿移动过程中iNOS的表达及意义 |
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| 引用本文： | 李伟宏,曹真胜,林新平.正畸牙齿移动过程中iNOS的表达及意义[J].口腔医学研究,2006,22(5):511-512. |
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| 作者姓名： | 李伟宏 曹真胜 林新平 |
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| 作者单位： | 温州医学院附属口腔医院正畸科,浙江,温州,325027;温州医学院附属口腔医院正畸科,浙江,温州,325027;温州医学院附属口腔医院正畸科,浙江,温州,325027 |
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| 摘 要： | 目的:观察诱导型一氧化氮合酶(induc ib le n itric oxide synthase,iNOS)在大鼠正畸牙齿移动引发牙周组织改建过程中的表达,探讨NO/iNOS在正畸牙齿移动中的作用机制。方法:56只雄性SD大鼠随机分为8组。分别在正畸加力1,3,5,7,14,21,28 d后进行免疫组化染色和图像分析。结果:正畸加力3 d后,牙周组织细胞iNOS表达增强,7 d iNOS表达达到高峰(P<0.01),以后iNOS表达下降。结论:NO/iNOS参与了正畸牙周组织改建过程。
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| 关 键 词： | 诱导型一氧化氮合酶 牙移动 |
| 文章编号： | 1671-7651(2006)05-0511-02 |
| 修稿时间： | 2006年3月2日 |
Expression of iNOS during Experimental Tooth Movement |
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| LI Wei-Hong,CAO Zhen-Sheng,LIN Xin-ping.Expression of iNOS during Experimental Tooth Movement[J].Journal of Oral Science Research,2006,22(5):511-512. |
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| Authors: | LI Wei-Hong CAO Zhen-Sheng LIN Xin-ping |
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| Institution: | LI Wei-Hong,CAO Zhen-Sheng,LIN Xin-ping.Hospital of Stomatology,Wenzhou Medical College,Wenzhou 325027 |
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| Abstract: | Objective: To observe the expression change of inducible nitric oxide synthase(iNOS) in orthodontic periodontal tissue remodeling,learn the role of NO/iNOS during experimental tooth movement in rats.Methods: 56 male SD rats were randomly divided into 8 groups.Orthodontic appliance was placed between the maxillary right first molar and maxillary central incisors of rat.Immunohistochemistry and image analyses were performed at 0,1,3,5,7,14,21,28 days after orthodontic force application.Results: The expression of iNOS was weak immunoreactivities in normal periodotium.3 days after tooth movement,the immunoreactivities of iNOS were increased,and reached the maximum after 7days.Conclusion: NO/iNOS participate in orthodontic periodontal tissue remodeling during tooth movement. |
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| Keywords: | Inducible nitric oxide synthase Tooth movement |
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