慢性粒细胞白血病患者核型分析及预后意义探讨

目的：探讨慢性粒细胞白血病（CML）患者核型变化的有关特点及预后意义。方法：染色体制备采用骨髓细胞短期培养法,应用R显带技术对64例CML患者的骨髓细胞进行遗传学分析。结果：64例CML患者中,53例检出典型费城染色体（Ph）,2例为变异Ph易位,2例Ph阴性,6例核型呈嵌合状态,5例出现附加染色体异常,主要为＋8、-17、-y、-21等。其中3例为加速和急变期患者。结论：CML是一种高度异质性疾病,非随机的附加染色体异常与患者临床分期高度相关,CML患者进行染色体分析对于疾病的诊断及鉴别、指导临床治疗、判断预后具有重要意义。

To Explore the Charateristic and Prognosis of Chromosome Changes in Patients with Chronic Myeloid Leukemia

Objective：To explore the characteristic and prognosis of chromosome changes in patients with chronic myeloid leukemia . Methods： The chromosomes were obtained by short culturing of bone marrow cell and analyed under microscope after R - banding. Results： 64 patients with CML, 53 cases were Ph positive, 2 cases were variant Ph translocations, 2 cases were Ph negative , 6 cases were the chimer Ph positive and Ph negative. In 5 cases beside the Ph positive, the additional chromosome abnormality were detected, such as ＋ 8、- 17、 - y、- 21,3 cases were in accelerated and balstic phase. Conclusion： The occurrence of additional chromosome abnormality is highly correlative to the clinical phase of the patients . The chromosome analysis was not only useful to the diagnosis and the differentiate, but also importance for the treatment as well as prognosis.