尼膜同治疗急性脑出血的前瞻性研究

目的 :将实验性脑出血的缺血性损害理论用于临床 ,观察尼膜同静脉输注治疗急性脑出血的临床疗效。方法 :应用前瞻性随机单盲方法 ,对 182例经CT证实的急性脑出血病人 ,在起病 72h内随机接受尼膜同或单纯甘露醇治疗 ,以神经功能缺损程度积分差及CT上血肿吸收率为指标 ,比较两组疗效。结果 :尼膜同组在各个时点上神经功能缺损的平均减少分数以及CT上血肿吸收率均优于常规治疗组。结论 :尼膜同是治疗急性脑出血的一种安全、有效的新方法。

A Prospective Study of Nimotop in the Treatment of Acute Intracerebral Hemorrhage

Objective The purpose of the study was to applying the mechanisms of ischemic brain after experimental intracerebral hemorrhage.Methods With the prospective random single blind method, 182 cases of acute intracerebral hemorrhage patients who are confirmed by CT scan randomly accepted the treatment of nimotop or pure mannitol within 72 hours after onset of hemorrhage.The two groups are compared with the indexes of the score difference of neurologic defects and the hematomas absorptive rate.Result The average decreased scores of neurologic defects with treatment of nimotop at each time point and the hematoma absorptive rate are better than that in the routine treatment group.Conclusion Nimotop is a safe and effective new method in treatment of acute intracerebral hemorrhage.