The mismatch negativity to frequency deviant stimuli during natural sleep |
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| Institution: | 1. Cardiologie pédiatrique, centre de référence malformations cardiaques congénitales complexes, hôpital universitaire Necker-Enfants–Malades, Assistance publique des Hôpitaux de Paris, 75015 Paris, France;2. Service de radiologie pédiatrique, hôpital universitaire Necker-Enfants–Malades, Assistance publique des Hôpitaux de Paris, 75015 Paris, France;3. Université Paris V Descartes, 75006 Paris, France;1. School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;2. School of Naval Architecture, Ocean and Civil Engineering, MOE Key Laboratory of Hydrodynamics, Shanghai Jiao Tong University, Shanghai 200240, China;1. Helen Wills Neuroscience Institute, University of California – Berkeley, Berkeley, CA, USA;2. Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway;3. Department of Neuropsychology, Helgeland Hospital, Mosjøen, Norway;4. Department of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital – Rikshospitalet, Oslo, Norway;5. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;6. Department of Psychology, University of California – Berkeley, Berkeley, CA, USA;1. Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Virchowstrasse 174, 45147 Essen, Germany;2. Department of Psychology, University of Wuppertal, Gaußstrasse 2 0, 42119 Wuppertal, Germany;3. Department of Addiction Medicine and Addictive Behavior, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Virchowstrasse 174, 45147 Essen, Germany;1. Laboratoire de Recherche en Neuroimagerie (LREN), University Hospital (CHUV) & University of Lausanne, Switzerland;2. Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland;3. Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland;4. Department of Intensive Care Medicine, University Hospital (CHUV) & University of Lausanne, Switzerland;5. Neurology Service, University Hospital (CHUV) & University of Lausanne, Switzerland |
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| Abstract: | Eight subjects spent a single night in the sleep laboratory. Event-related potentials (ERPs) were recorded during the presentation of two auditory ‘oddball’ stimulus conditions in which tonal frequency was manipulated. In the first condition, 1000 Hz ‘standard’ and 2000 Hz ‘deviant’ tones were presented. In the second condition, the deviant tone was reduced to 1050 Hz. In both conditions, deviant probability was 0.2. Stimuli were presented every 600 ms during wakefulness and stages 2, 4, and REM of sleep. A distinctive N1 wave was visible in both stimulus conditions when the subject was awake. The deviant stimuli elicited a ‘mismatch negativity’ (MMN) that inverted in polarity at the mastoid. In REM sleep, an N1 and a MMN were also elicited in both conditions. In the large deviance condition, the MMN had a slightly attenuated amplitude and was shorter in duration while in the small deviant condition, its peak latency was unusually early. Neither the N1 nor the MMN could be recorded in non-REM sleep. |
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