Pharmacokinetics of Miocamycin Following Intravenous Administration to Cattle

The plasma pharmacokinetics for a single intravenous dose (10 mg/kg body weight) of miocamycin (a 16‐membered macrolide drug) was investigated in Holando Argentino cattle (n = 5). Blood drug concentrations were determined by a microbiological method and data were best‐fitted to a two‐compartment open model. The pharmacokinetic profile consisted of a short distribution phase (t_1/2α = 7.41 ± 0.53 min), followed by an extended terminal elimination phase (t_1/2β = 2.49 ± 0.23 h). The volume of distribution at steady‐state was large (2.13 ± 0.17 l/kg), suggesting extensive tissue distribution, the clearance value was 0.60 ± 0.03 l/h.