| 炎症介质与肿瘤血管生成 |
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| 引用本文： | 梅鑫,陈银生,陈忠平. 炎症介质与肿瘤血管生成[J]. 中国神经肿瘤杂志, 2012, 0(3): 184-188 |
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| 作者姓名： | 梅鑫 陈银生 陈忠平 |
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| 作者单位： | 中山大学肿瘤防治中心神经外科/神经肿瘤科 |
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| 基金项目： | 国家自然科学基金资助项目(No.30571914,No.30973478) |
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| 摘 要： | 炎症介质不仅在肿瘤的发生发展过程中起到了重要的作用,在肿瘤的血管生成方面也扮演着重要的角色。炎症反应的调节通路和肿瘤血管生成调节通路存在较大的重叠。研究证实,包括COX-2、IL-1、IL-6等在内的众多炎症介质不仅能够促进肿瘤血管生成,在肿瘤血管拟态形成及肿瘤干细胞向血管内皮细胞定向分化过程中可能也起到积极的促进作用。
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| 关 键 词： | 炎症介质 血管生成 肿瘤干细胞 |
Mediators of inflammation and tumor angiogenesis |
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| Xing Mai,Ying-sheng Chen,Zhong-ping Chen. Mediators of inflammation and tumor angiogenesis[J]. Chinese Journal of Neuro-Oncology, 2012, 0(3): 184-188 |
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| Authors: | Xing Mai Ying-sheng Chen Zhong-ping Chen |
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| Affiliation: | Department of Neurosurgery,Sun Yat-sen University Cancer Center, Guangzhou 510060,P.R.China |
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| Abstract: | Mediators of inflammation play a key role in tumor development and angiogenesis. The pathways controlling inflammation response share a lot common in that inducing tumor angiogenesis. It has been reported that inflammation mediators, such as COX-2, IL-1 and IL-6, can promote tumor angiogenesis. But they may also take the positive effect in formation of vascular mimicry and differentiation of cancer stem cells to vascular endothelial cell. |
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| Keywords: | Mediators of inflammation Angiogenesis Cancer stem cell |
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