Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure |
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Authors: | Klingenheben T Zabel M D'Agostino R B Cohen R J Hohnloser S H |
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Affiliation: | MA Inst Tech, Cambridge |
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Abstract: | Measurement of microvolt level T-wave alternans in the surface electrocardiogram is a novel way to assess the risk of ventricular arrhythmias. Seven tests of arrhythmic risk, including T-wave alternans, were undertaken in 107 consecutive patients with congestive heart failure and no history of sustained ventricular arrhythmias; the patients were followed up for arrhythmic events during the next 18 months. Of the patients with events, 11 had positive and two indeterminate T-wave alternans results; there were no arrhythmic events among patients with negative T-wave alternans results. Of the seven tests, only T-wave alternans was a significant (p=0.0036) and independent predictor of arrhythmic events. |
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