Tenascin在鼻息肉组织中的表达及其临床意义

目的：探讨Tenascin(TN)在鼻息肉组织中的表达和分布特征及其在鼻息肉发生中的可能作用。方法：采用免疫组化链霉菌抗生物素蛋白—过氧化物酶(SP)法检测24例鼻息肉标本(鼻息肉组)和15例慢性肥厚性鼻炎下鼻甲标本(下鼻甲组)中TN的表达，并以5例健康者(对照组)下鼻甲黏膜作对照。结果：鼻息肉组和下鼻甲组黏膜上皮细胞及腺上皮细胞均表达TN；鼻息肉组TN的黏膜上皮阳性细胞表达的吸光度值显著高于下鼻甲组(P＜0．01)；鼻息肉组TN的腺上皮阳性细胞表达的吸光度值显著高于下鼻甲组(P＜0．01)；对照组下鼻甲组织中黏膜上皮及腺体几乎检测不到TN的表达；鼻息肉组腺体TN阳性率明显高于下鼻甲组(P＜0．05)。结论：TN在鼻息肉组织中的高表达与鼻息肉的发生、发展相关；TN在鼻腔内的表达细胞是黏膜上皮细胞和浆液性腺上皮细胞。

Expression of tenascin in human nasal polyp tissue and primary studies of its clinical significance

Objective:To explore the pathogenesis of nasal polyposis and the expression of tenascin in human nasal polyps.Method:Tenascin in nasal polyp tissues from twenty-four polyposis patients and tenascin in inferior turbinates tissues from fifteen chronic hypertrophic rhinitis patients were detected with immunohistochemistry (sp) method. The inferior trubinate mucosa of five healthy volunteers were selected as control.Result:Tenascin were expressed in the mucosa epithelial cells and serous cells from nasal polyps and inferior turbinates of chronic hypertrophic rhinitis;The level of tenascin in the mucosa epithelial cells from nasal polyps were significantly(P< 0.01); The level of tenascin in the serous cells from nasal polyps were significantly higher than that in inferior turbinates of chronic hypertrophic rhinitis(P< 0.01); Tenascin were hardly detected in nasal mucosa from healthy volunteers; The tenascin positivity in glandular cell was significantly higher in nasal phlyps than in inferior turbinates of chronic hypertrophic rhinitis (P< 0.05).Conclusion:There is close relationship between tenascin and nasal polyps.Tenascin is strongly expressed in nasal polyps and its mucosa, where it could be produced by mucosa epithelial cells and serous cells.