DISPOSITION OF NALBUPHINE IN PATIENTS UNDERGOING GENERAL ANAESTHESIA |
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| Authors: | SEAR, J. W. KEEGAN, M. KAY, B. |
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| Affiliation: | Nuffield Department of Anaesthetics, John Radcliffe Hospital Headington, Oxford, OX3 9DU
University Department of Anaesthesia, University Hospital of South Manchester Withington, Manchester M20 8LR. |
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| Abstract: | The pharmacokinetics of nalbuphine 20 mg i.v. were studied in10 patients undergoing lower abdominal or body surface surgery.Blood sampling was carried out for 600 min after injection anddrug concentrations were measured by HPLC using electrochemicaldetection. Disposition was best described as a triexponentialfunction, with a mean elimination half-life of 135.5 min. Meanresidence time, clearance, and volumes of distribution, Vssand Vß, were determined by a model independent method,and gave mean values of 149·7 min (MRT), 1095 ml min1(Cl ), 159·9 litre (Vss) and 207.1 litre(Vß). |
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