| 长春瑞滨与表阿霉素联合治疗晚期乳腺癌临床观察 |
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| 引用本文： | 李毅刚,卢路定,赖淑贞,曾庆祉. 长春瑞滨与表阿霉素联合治疗晚期乳腺癌临床观察[J]. 中国肿瘤临床与康复, 2005, 12(5): 419-420 |
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| 作者姓名： | 李毅刚 卢路定 赖淑贞 曾庆祉 |
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| 作者单位： | 广东省粤北人民医院肿瘤内科,广东韶关,512026 |
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| 摘 要： | 目的评价长春瑞滨联合表阿霉素治疗晚期乳腺癌的疗效和毒副反应.方法长春瑞滨25 mg/m2,d1,8;表阿霉素80 mg/m2,d1,静注.结果 43例中CR 4例(9.3%),PR 21例(48.8%),SD 13例(30.2%),PD 5例(11.6%),总有效率(CR PR)58.1%.其中既往曾用CMF方案化疗的19例患者,有效率为63.2%;曾用FAC方案化疗的24例有效率为54.2%.毒副反应主要是骨髓抑制,其次是静脉炎.结论长春瑞滨联合表阿霉素治疗晚期乳腺癌有较好疗效,毒副反应可以耐受.
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| 关 键 词： | 乳腺肿瘤/化学疗法 长春瑞滨 表阿霉素 |
| 文章编号： | 1005-8664(2005)05-0419-02 |
| 修稿时间： | 2004-12-10 |
Clinical observation of combination of vinorelbine and epirubicin for treatment of advanced breast cancer |
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| LI Yi-gang,LU Lu-ding,LAI Shu-zhen,et al. Clinical observation of combination of vinorelbine and epirubicin for treatment of advanced breast cancer[J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2005, 12(5): 419-420 |
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| Authors: | LI Yi-gang LU Lu-ding LAI Shu-zhen et al |
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| Abstract: | Objective To evaluate the efficacy and toxicity of chemotherapy with vinorelbine-epirubicin combination in the treatment of advanced breast cancer.Methods Forty-three patients with advanced breast cancer were included.VLB was administered on days 1 and 8 at a dose of 25 mg/m~2 and EPI at a dose of 80 mg/m~2 on d1 by intravenous infusion.Results The overall effective rate was 58.1%.The effective rate of the cases who had once receiving chemotherapy with CMF was 63.2%,and that of the other cases once receiving FAC was(54.2%).The main toxicity was bone marrow suppression,and then phlebitis.Conclusions Chemotherapy with VLB-EPI is effective for advanced breast cancer and the toxicity can be tolerated. |
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| Keywords: | Breast neoplasms/chemotherapy Vinorelbine Epirubicin |
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