| 生长激素、生长抑素对组织愈合影响的研究 |
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| 引用本文： | 姜军,顾军,刘放南,刘铁飞,张新华,任建安,黎介寿. 生长激素、生长抑素对组织愈合影响的研究[J]. 解放军医学杂志, 2001, 26(2): 99-101 |
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| 作者姓名： | 姜军 顾军 刘放南 刘铁飞 张新华 任建安 黎介寿 |
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| 作者单位： | 南京南京军区南京总医院 |
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| 基金项目： | 全军“九五”科研基金资助课题!(编号 98M 0 2 9) |
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| 摘 要： | 了解在全肠外营养（TPN）条件下，生长激素、生长抑素对组织愈合的确切作用。在TPN大鼠应用生长激素、生长抑素后发现；生长激素可促进血浆总蛋白、白蛋白和羟脯氨酸浓度提高，同时增加了肉芽组织中羟脯氨酸和纤维母细胞含量。而生长抑素则可降低血浆蛋白、羟脯氨酸浓度和肉芽组织中羟脯氨酸和纤维母细胞水平。提示了生长激素可促进机体和肉芽局部蛋白合成、组织愈合，而生长抑素在TPN条件下对蛋白合成和组织愈合有一定抑制作用。
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| 关 键 词： | 生长激素 生长抑素 组织愈合 影响 全肠外营养 TPN |
EXPERIMENTAL STUDY OF EFFECTS OF GROWTH HORMONE AND SOMATOSTATIN ON WOUND HEALING |
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| Jiang Jun,Gu Jun,Liu Fangnan et al. General Hospitnl of Nanjing Gommand,Nanjing. EXPERIMENTAL STUDY OF EFFECTS OF GROWTH HORMONE AND SOMATOSTATIN ON WOUND HEALING[J]. Medical Journal of Chinese People's Liberation Army, 2001, 26(2): 99-101 |
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| Authors: | Jiang Jun Gu Jun Liu Fangnan et al. General Hospitnl of Nanjing Gommand Nanjing |
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| Affiliation: | Jiang Jun,Gu Jun,Liu Fangnan et al. General Hospitnl of Nanjing Gommand,Nanjing 210002 |
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| Abstract: | To observe the effects of growth hormone and somatostatin on wound healing during total parenteral nutrition(TPN). After using growth hormone and somatostatin on TPN rats, the results showed that growth hormone improved levels of plasma total protein,albumin and hydroxyproline, and also increased concentrations of hydroxyproline and fibroblast in granulation tissue. While somatostatin reduced levels of plasma protein, hydroxyproline and fibroblast, and granulation tissue hydroxyproline. It suggested that growth hormone could accelerates whole body and granulation tissue protein synthesis or wound healing, somatostatin sometimes partly inhibits body protein synthesis and wound healing. |
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| Keywords: | growth hormone somatostatin healing |
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