| 联合化疗对膀胱癌细胞株BIU-87及其耐药亚株联合抑制作用的体外实验研究 |
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| 引用本文： | 陈忠,杨为民,杜广辉,叶章群,曾晓勇,杨业金. 联合化疗对膀胱癌细胞株BIU-87及其耐药亚株联合抑制作用的体外实验研究[J]. 华中科技大学学报(医学版), 2002, 31(3): 301-303 |
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| 作者姓名： | 陈忠 杨为民 杜广辉 叶章群 曾晓勇 杨业金 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院泌尿外科,武汉,430000
2. 华中科技大学同济医学院基础医学院生物化学与分子生物学系,武汉,430030 |
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| 摘 要： | 实验采用微量细胞培养噻唑蓝显色法观察阿霉素（ADM）、足叶乙甙（VP－16）、丝裂霉素C（MMC）和羟基喜树碱（HCPT）等药物联合应用于膀胱癌细胞株BIU－87及其耐药亚株BIU－87／A、BIU－87／V，结果显示：HCPT与MMC、ADM联合应用对亲本及耐药细胞株都能取得较好抑制作用。联合用药能增强化疗药物对BIU－87细胞的毒性作用，并能克服耐药肿瘤细胞的多药耐药性。
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| 关 键 词： | 联合化疗 膀胱癌 细胞株 BIU－87 耐药亚株 抗肿瘤药 多药耐药性 实验研究 药物疗法 |
In Vitro Experimental Study on the Effects of Combined Chemotherapy on Bladder Cancer Cell BIU-87 and Its Multidrug Resistance Lines |
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| Chen Zhong,Yang Weimin,Du Guanghui et al. In Vitro Experimental Study on the Effects of Combined Chemotherapy on Bladder Cancer Cell BIU-87 and Its Multidrug Resistance Lines[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2002, 31(3): 301-303 |
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| Authors: | Chen Zhong Yang Weimin Du Guanghui et al |
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| Affiliation: | Chen Zhong,Yang Weimin,Du Guanghui et al Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | The MTT assay was used to study the combined chemotherapy of adriamycin (ADM),etoposide (VP 16), mitomycin C (MMC) and hydroxycamptothecine (HCPT) in the treatment of human bladder cancer cell line BIU 87 and its multidrug resistance lines BIU 87/A, BIU 87/V in vitro . Results showed that combined use of HCPT and MMC or ADM had a better synergistic cytotoxicity against the three lines. Combined chemotherapy can increase cytotoxicity against BIU 87 and BIU 87/A, BIU 87/V, and also can overcome multidrug resistance. |
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| Keywords: | bladder neoplasms cell line antineoplastic agents combined multidrug resistance |
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