| 健骨冲剂对去卵巢骨质疏松大鼠血清ALP,NOS活性及NO含量的影响 |
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| 引用本文： | 张洋,李亚东,李健男. 健骨冲剂对去卵巢骨质疏松大鼠血清ALP,NOS活性及NO含量的影响[J]. 时珍国医国药, 2007, 18(7): 1651-1652 |
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| 作者姓名： | 张洋 李亚东 李健男 |
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| 作者单位： | 黑龙江中医药大学,黑龙江,哈尔滨,150040 |
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| 摘 要： | 目的观察健骨冲剂对去卵巢雌性骨质疏松大鼠血清碱性磷酸酶(ALP)、一氧化氮合酶(NOS)活性及一氧化氮(NO)含量的影响。方法以去卵巢雌性大鼠骨质疏松为模型,通过给药60 d后,与模型对照组比较血清ALP,NOS活性和NO含量。结果健骨冲剂组大鼠血清ALP,NOS活性及NO含量明显高于模型组(P<0.01)。结论中药健骨冲剂能显著提高血清ALP,NOS活性及NO含量,从而作用于成骨细胞促进骨形成,调节骨重建过程。
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| 关 键 词： | 健骨冲剂 骨质疏松 碱性磷酸酶 一氧化氮合酶 一氧化氮 |
| 文章编号： | 1008-0805（2007）07-1651-01 |
| 收稿时间： | 2006-11-23 |
| 修稿时间： | 2006-11-232007-02-03 |
Changes of Serum ALP, NO and NOS in Osteoporosis Model Rats Treated with JianGu Granule |
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| ZHANG Yang,LI Ya-dong,LI Jian-nan. Changes of Serum ALP, NO and NOS in Osteoporosis Model Rats Treated with JianGu Granule[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(7): 1651-1652 |
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| Authors: | ZHANG Yang LI Ya-dong LI Jian-nan |
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| Affiliation: | Heilongjiang University of Chinese Medicine, Heilongjiang, Harbin 150040, China |
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| Abstract: | Objective To observe the changes of serum ALP,NO and NOS in the ovariectomized osteoporosis rats treted with Jiangu granule(JGCJ).Methods After fed for 60 days,the ovariectomized rats group with JGCJ were examined and compared with the group without JGCJ.Results The levels of ALP,NO and NOS in group with JGCJ were significantly higher than those of the group without JGCJ.Conclusion The Chinese medicine JGCJ can significantly increase the level of ALP,NO and NOS in the ovariectomized model rats' serum,facilitate formation of bone cell and adjust restructure of bone. |
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| Keywords: | JianGu granule Osteoporosis ALP NOS NO |
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