| 造血细胞因子EPO、SCF、GM-CSF在慢性再生障碍性贫血患者骨髓中的表达 |
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| 引用本文： | 王琰,徐瑞荣. 造血细胞因子EPO、SCF、GM-CSF在慢性再生障碍性贫血患者骨髓中的表达[J]. 中国实验血液学杂志, 2008, 16(5): 1100-1102 |
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| 作者姓名： | 王琰 徐瑞荣 |
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| 作者单位： | 山东中医药大学附属医院,山东济南,250011 |
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| 摘 要： | 本研究探讨造血细胞因子EPO、SCF、GM-CSF在慢性再生障碍性贫血（chronic aplastic anemia，CAA）患者骨髓中的表达水平及其意义。应用RT—PCR法半定量检测35例CAA患者及10例正常人骨髓标本中EPO、SCF、GM-CSF mRNA表达。结果表明：CAA患者骨髓中EPO、SCF、GM—CSF水平均明显低于正常人（p〈0．01）。结论：慢性再生障碍性贫血患者存在造血细胞因子介导的免疫紊乱的病理机制，这为指导临床治疗提供了理论依据。
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| 关 键 词： | 慢性再生障碍性贫血 造血调控 细胞因子 EPO SCF GM—CSF |
Expression of Hematopoietic Cytokines EPO,SCF and GM-CSF in Bone Marrow Cells of Patients with Chronic Aplastic Anemia |
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| WANG Yan,XU Rui-Rong. Expression of Hematopoietic Cytokines EPO,SCF and GM-CSF in Bone Marrow Cells of Patients with Chronic Aplastic Anemia[J]. Journal of experimental hematology, 2008, 16(5): 1100-1102 |
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| Authors: | WANG Yan XU Rui-Rong |
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| Affiliation: | Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong Province, China. |
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| Abstract: | The objective of this study was to investigate the expressions of hematopoietic cytokines EPO,SCF and GM-CSF in bone marrcw cells of patients with chronic aplastic anemia(CAA) and their significance.The mRNA expressions of EPO,SCF and GM-CSF from 35 CAA patients and 10 healthy individuals were detected by stmi-quanti-tative RT-PCR.The results showed that the levels of EPO,SCF and GM-CSF in CAA patients were obviously lower than those in the healthy individuals(p<0.01).It is concluded that the immunity disorder mediated by hematopoietic cytokines is one of the pathogenesis in the CAA patients,it provided theoretical basis for guiding clinical treatment. |
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| Keywords: | chronic aplastic anemia hematopoietic cytokine EPO SCF GM-CSF |
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