Fatal varicella associated with selective natural killer cell deficiency |
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| Authors: | Etzioni Amos Eidenschenk Celine Katz Rina Beck Rafeal Casanova Jean Laurent Pollack Shimon |
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| Affiliation: | Meyer Children's Hospital, Department of Immunology, B. Rappaport Medical School, Technion, Haifa, Israel. etzioni@rambam.health.gov.il |
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| Abstract: | A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herpes viral infection. |
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| Keywords: | Ig, Immunoglobulin IL, Interleukin NK, Natural killer VZV, Varicella-zoster virus |
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