食管鳞癌组织中桩蛋白和血管细胞粘附分子-1的表达及其意义

目的 探讨桩蛋白和血管细胞粘附分子(VCAM)-1在食管鳞癌组织中的表达及其与食管鳞癌细胞发生、发展和转移的关系.方法应用免疫组化SP法检测24例正常食管黏膜、94例食管鳞癌组织中VCAM-1和桩蛋白的表达情况.结果桩蛋白表达率与淋巴结转移、浸润深度和临床分期等因素显著相关(P<0.05、P<0.01、P<0.01);VCAM-1与浸润深度、淋巴结转移和临床分期等因素有关(P<0.01、P<0.05、P<0.01).桩蛋白与VCAM-1在癌组织中表达相关(列联r=0.247,P<0.05).结论桩蛋白和VCAM-1在食管鳞癌组织中高表达,可作为评价食管鳞癌生物学行为的指标.

Expression and significance of Paxillin and VCAM-1 proteins in esophageal carcinoma

Objective To study the expression of Paxillin and VCAM-1 in esophageal carcinoma and the relationship between the expression of Paxillin, VCAM-1 and carcinogenesis and progression of esophageal carcinoma. Methods Paxillln and VCAM-1 expression were detected in 24 normal esophageal mucosa and 94 primary tumor tissues with SP immunohistochemistal method. Results The expression rate of PaxiUin was related to invasive depth (P <0.01) ,clinical staging (P <0.01) and metastasis of lymph node (P <0.05). The expression rate of VCAM-1 was related to invasive depth (P < 0.01) ,clinical staging (P < 0.01) and metastasis of lymph node (P<0.05). There was a positive correlation between Paxillin and VCAM-1 expression in this study (r = 0. 247 ,P < 0.05). Conlusion Paxillin and VCAM-1 are over expressed in esophageal carcinoma. They can be used as valuable biomakers to evaluate biological characteristics in esophageal carcinoma.