| 大鼠微粒体代谢酶对黄芩素葡萄糖醛酸化代谢物影响的实验研究 |
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| 引用本文： | 关小彬,叶玲,夏笔军,刘中秋.大鼠微粒体代谢酶对黄芩素葡萄糖醛酸化代谢物影响的实验研究[J].中国临床药理学杂志,2009,25(4). |
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| 作者姓名： | 关小彬 叶玲 夏笔军 刘中秋 |
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| 作者单位： | 1. 广州中医药大学广东省中医院珠海医院药剂科,广东,珠海,519015
2. 南方医科大学药学院药剂学系,广州,510515 |
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| 摘 要： | 目的 观察大鼠微粒体代谢酶对黄芩素(治疗呼吸道感染中药)代谢作用的影响.方法 用体外微粒体药物代谢酶孵育法;用HPLC法测定黄芩素及其葡萄糖醛酸化代谢物的含量,在不同孵育时间和不同浓度下,观察大鼠肝肠不同微粒体对黄芩素葡萄糖醛酸化代谢产物生成速率的影响.结果 5种不同微粒体药物代谢酶对黄芩素均有代谢作用,且随孵育时间延长,代谢作用也相应增加,呈较好的时间和剂量依赖关系.在5种微粒体中,十二指肠微粒体代谢作用最强;而肝代谢作用最弱.结论 黄芩素主要代谢部位是肠道.
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| 关 键 词： | 黄芩素 微粒体 代谢 |
Experimental study on specific glucuronidation of baicalein by liver and intestine microsomes in rats |
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| GUAN Xiao-bin,YE Ling,XIA Bi-jun,LIU Zhong-qiu.Experimental study on specific glucuronidation of baicalein by liver and intestine microsomes in rats[J].The Chinese Journal of Clinical Pharmacology,2009,25(4). |
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| Authors: | GUAN Xiao-bin YE Ling XIA Bi-jun LIU Zhong-qiu |
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| Institution: | 1.Department of Pharmacy;Zhuhai Division of Guangdong Affiliated Hospital of Chinese Medicine;Guangzhou University of Chinese Medicine;Zhuhai 519015;Guangdong Province;China;2.Department of Pharmaceutics;School of Pharmaceutical Sciences;Southern Medical University;Guangzhou 510515;China |
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| Abstract: | Objective To investigate the different roles of metabolism of baicalein in rat,especial liver and intestine.Methods The enzyme reactions by microsome incubations were employed.The content of baicalein and baicalein-glucuronide were determined by HPLC.The glucuronidation rates of baicalein at different time points and at various concentrations were measured by using 5 UGT microsomes.Results Five different microsomes are important common microsomes for glucuronidation of baicalein with the manner of time and ... |
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| Keywords: | baicalein microsomes metabolism |
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