加味补阳还五汤对缺血性卒中患者Hcy、CRP和Barthel指数评分的影响

目的 观察加味补阳还五汤对缺血性卒中患者急性、亚急性期和恢复期血浆同型半胱氨酸( Hcy)、血清C反应蛋白(CRP)和Barthel指数评分的影响.方法 缺血性卒中患者(82人)随机分为补阳还五汤治疗组(42人)、对照组(40人),疗程4周,随访180天,分别在治疗14、28、90天后检测两组患者Hcy、CRP,进行Barthel指数评分.180天后统计心脑血管事件发生率.结果 Hcy:治疗14天后治疗组较治疗前明显下降(P＜0.01),对照组治疗28天后较治疗前下降,但治疗组明显优于对照组(P＜0.01)；CRP:14天治疗组较治疗前明显下降(P＜0.05),对照组治疗28天后较治疗前下降,但治疗组明显优于对照组(P＜0.01)；Barthel指数评分:治疗14天后治疗组治疗前、后差异明显,后者提高(P＜0.01),治疗28天后两组患者均提高,但治疗组优于对照组(P＜0.05,P＜0.01).90天后治疗组各项指标均优于对照组(P＜0.01)；180天时治疗组患者出现1例(2.38％)心脑血管复发事件；对照组患者出现3例(7.5％)心脑血管复发事件,两组之间差异有统计学意义(P＜0.05).结论 加味补阳还五汤对缺血性卒中急性期和亚急性期的治疗有效,恢复期能够降低脑血管事件复发率.

NFLUENCE OF MODIFIED BUYANGHUANWU DECOCTION ON PATIENTS WITH ISCHEMIC STROKE EVALUATED BY Hcy, CRP AND Barthel INDEX SCORE

Objective To explore the influence modified Buyanghuanwu decoction on patients with ischemic stroke evaluated by the levels of Homocysteine(Hcy),C-reaction protein(CRP) and Barthel index score.Methods Randomly diveded 82 patients with ischmic stroke into two groups:Buyanghuanwu group(42 patients)and Control group(40 patients);treated for 4 weeks as a course and followed-up for 180 days and the Hcy and CRP were detected at 14th d,28th d and 90th d,respectively,after treatment,and then the Barthel index score was evaluated.The events of incidence for cadiocerebralvacular diseases were calculted after 180 d.Results Hcy:the level of Hcy was significantly reduced in Buyanghuanwu group than control group after 14ds treatment(P<0.01).The Hcy level in control group treated by routine treatment for 28ds was reduced when compared with itself before treatment or Buyanghuanwu group(P<0.05 or P<0.01).CRP:the level of CRP was significantly reduced in Buyanghuanwu group than control group after 14ds treatment(P<0.01).The Hcy level in control group treated by routine treatment for 28ds was reduced when compared with itself before treatment or Buyanghuanwu group(P<0.05 or P<0.01)Barthel index score:the score was significantly increased in Buyanghuanwu group than control group after 14ds,28ds and 90ds treatment,respectively(P<0.01,P<0.05 and 0.01).There was 1case(2.38%) and 3 cases(7.5%) of cadiocerebralvacular recurrence events appeared in Buyanghuanwu group and control group,respectively,at 180th d after treatment,and there showed significant difference between two groups(P<0.05).Conclusion Modified Buyanghuanwu Decoction shows effectiveness on acute and subacute ischemic stroke and reduces the recurrence rate of adiocerebralvacular events in the stage of restoration.