沙棘总黄酮对血管性痴呆模型大鼠行为学和血液流变学的影响

目的 观察沙棘总黄酮(TFH)对血管性痴呆(VD)模型大鼠行为学和血液流变学的影响.方法 ①采用改进的“高脂血症血管性痴呆”法进行造模.②利用Morris水迷宫对模型大鼠进行行为学测试.③取血检测相关血液流变学指标.结果 ①定位航行实验:各组和假手术组相比,有统计学意义(P＜0.05)；对照组、实验组(中、高剂量组)与模型组相比,有统计学意义(P＜0.05).②空间探索实验:各组与假手术组相比,有统计学意义(P＜0.05)；假手术组、对照组、实验组(中、高剂量组)与模型组相比,有统计学意义(P＜0.05).③血流变学:对照组、实验组与假手术组相比,有统计学意义(P＜0.05)；对照组、实验组与模型组相比,有统计学意义(P＜0.05).结论 沙棘总黄酮能改善血管性痴呆模型大鼠的学习记忆能力,且能改善全血黏度及血浆黏度.

EFFECTS OF TOTAL FLAVONES Hippophae RHAMNOIDES ON BEHAVIOR AND BLOOD RHEOLOGY IN RAT MODEL OF VASCULAR DEMENTIA

objective To observe the effects of Total Flavones Hippophae(TFH) on behavior and blood rheology of vascular dementia(VD) in rats.Methods ①Using the improved "hyperlipidemia vascular dementia" to make vascular dementia model.②Using the Morris water maze on the model rats to test the behavior.③Testing blood rheology of rats.Results ①Place navigation test:Comparison groups with sham operation group showed statistical significance(P<0.05).Compared the control group and the experimental group(middle,high dose group) with the model group have shown statistical significance(P<0.05).②Space navigation test: compared groups with sham operation group have shown statistical significance(P<0.05).Compared the sham operation group,the control group and the experimental group(middle,high dose group)with the model group have shown statistical significance(P<0.05).③blood rheology:Compared the control group and the experimental group with sham operation group have shown statistical significance(P<0.05).Compared the control group and the experimental group with the model group have shown statistical significance(P<0.05).Conclusion Total Flavones Hippophae can improve the learning and memory ability of VD rats and can improve the whole blood viscosity and plasma viscosity.