| 诺氟沙星及其胶囊剂的质量控制 |
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| 引用本文： | 金虹,黄天俊,左承学. 诺氟沙星及其胶囊剂的质量控制[J]. 华西药学杂志, 2004, 19(1): 66-67 |
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| 作者姓名： | 金虹 黄天俊 左承学 |
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| 作者单位： | 西南科技大学生命科学与工程学院,四川,绵阳,621002;绵阳市中医药研究所,四川,绵阳,621000;绵阳市药品检验所,四川,绵阳,621000 |
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| 摘 要： | 目的 建立简便的诺氟沙星及其胶囊的质量控制方法，作为HPLC法的补充。方法采用性状理化特征鉴别、反相纸上色谱、薄层-乙酰胆碱酯酶抑制试验，紫外分光光度法定性和对照品法定量的分析。结果诺氟沙星胶囊的颜色反应、层析Rf值、抑制乙酰胆碱酯酶斑点和紫外特征吸收均与诺氟沙星对照品一致，而伪劣诺氟沙星胶囊有明显差异。诺氟沙星及其胶囊含量测定用紫外分光光度法，结果与高效液相色谱法一致。结论所用分析方法能有效控制诺氟沙星及其胶囊的质量，紫外法可作为现行药典方法的补充。
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| 关 键 词： | 诺氟沙星 质量控制 胶囊剂 吸收度比值 |
| 文章编号： | 1006-0103(2004)01-0066-02 |
| 修稿时间： | 2003-06-01 |
The quality control of Norfloxasin and its capsules |
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| JIN Hong ,HUANG Tian-jun ,ZUO Cheng-xue. The quality control of Norfloxasin and its capsules[J]. West China Journal of Pharmaceutical Sciences, 2004, 19(1): 66-67 |
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| Authors: | JIN Hong HUANG Tian-jun ZUO Cheng-xue |
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| Affiliation: | JIN Hong 1,HUANG Tian-jun 2,ZUO Cheng-xue 3 |
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| Abstract: | OBJECTIVE To establish an analytical method,as a supplement of HPLC,for controlling the quality of Norfloxacin and its capsule.METHODS Physical and chemical characteristics,RP-paper chromatography,acetylcholinesterase inhibiting TLC test and UV spectrophotometry were used to analyze Norfloxacin and its capsule qualitatively and quantitatively.RESULTS Norfloxacin and its capsule could be identified and measured by these analytical methods.CONCLUSION The methods are suitable for a supplement of China Pharmacopoeia in 2000. |
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| Keywords: | Norfloxacin Quality control Capsule Absorbance ratio |
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