| 头孢泊肟酯自乳化制剂的研究 |
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| 引用本文： | 全丹,高缘. 头孢泊肟酯自乳化制剂的研究[J]. 海峡药学, 2007, 19(3): 24-26 |
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| 作者姓名： | 全丹 高缘 |
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| 作者单位： | 海南三叶药业有限公司,海口,570216;中国药科大学,南京,210009 |
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| 摘 要： | 目的 优化制备头孢泊肟酯自乳化最佳处方条件使其达到目标浓度50mg·g-1.方法 通过溶解度实验、相图绘制、以及形成乳剂的乳化程度、乳滴粒径大小,对头孢泊肟酯自乳化体系中的油相、表面活性荆、助表面活性剂进行筛选,寻找最佳处方条件.结果 优选的头孢泊肟酯自乳化制剂处方中油相为Lauroglycol FCC,表面活性剂为Labrasol,助表面活性荆为Labrafil M1944 CS.结论 初步成功地制备了头孢泊肟酯自乳化传递体系.
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| 关 键 词： | 头孢泊肟酯 自乳化系统 粒径测定 伪三相图 |
| 文章编号： | 1006-3765（2007）03-0024-03 |
Studies on the self-emulsifying drug delivery systems of Cefpodoxime Proxetil |
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| QUAN-Dan,GAO-Yuan. Studies on the self-emulsifying drug delivery systems of Cefpodoxime Proxetil[J]. Strait Pharmaceutical Journal, 2007, 19(3): 24-26 |
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| Authors: | QUAN-Dan GAO-Yuan |
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| Affiliation: | Hainan Sanye Pharmaceutical CO. Ltd., Haikou 570216, China ; China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | OBJECTIVE To optimize the preparation conditions of SEDDS of CPDX-PR. METHODS To screen and optimize the oil phase, surfactant and pseudo-ternary phase diagram ,emulsion examination and droplet size determination. RESULTS The optimal oil phase, surfactant and co-surfactant was Lauroglycol FCC, Labrasol and Labrafil M1944 CS respectively. CONCLUSION The preliminary CPDX-PR SEDDS has been prepared. |
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| Keywords: | Cefpodoxime proxetil Self-emulsifying drug delivery systems Droplet size Pseudo-ternary phase diagram. |
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