Efficiency of embryotoxicity testing procedures: II. comparison between the official,mest and chest methods |
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| Authors: | Otakar Marhan Richard Jelínek |
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| Affiliation: | Research Institute for Pharmacy and Biochemistry, Konarovice, and Institute of Experimental Medicine, Czechoslovak Academy of Sciences, PragueCzechoslovakia |
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| Abstract: | 17 drugs were tested by 3 different embryotoxicity methods. The official routine procedure showed interspecies variance even between rat and rabbit. Evaluation based on the reaction of a single morphogenetic system after short-term treatment in the rat (MEST) is less laborious, inexpensive and quicker. Good results were obtained with chick embryos which, under strictly defined experimental conditions (CHEST), may prove a useful and reliable model in embryotoxicity screening. |
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| Keywords: | CHEST chick embryotoxicity screening test MEST mammal embryotoxicity screening test |
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