Carcinogenicity and nephrotoxicity of 2-amino-, 1-amino- 2-methyl-, and 2-methyl-1-nitro-anthraquinone |
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Authors: | A.S.Krishna Murthy Agnes B. Russfield Miasnig Hagopian Ruth Monson Jane Snell Elizabeth K. Weisburger |
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Affiliation: | 1. EG&G Mason Research Institute, Worcester, MA 01608 U.S.A.;1. National Cancer Institute, Bethesda, MD 20014 U.S.A. |
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Abstract: | 2-Aminoanthraquinone (AA), l-amino-2-methylanthraquinone (l-Am-2-MeA), and 2-methyl-l-nitroanthraquinone (2-Me-1-Na) were tested for carcinogenicity in Fischer 344 rats and B6C3F1 mice. In rats, all the 3 chemicals increased the incidence of hepatocellular neoplasms. Renal neoplasms were increased with 1-Am-2-MeA, and 2-Me-1-NA increased the incidence of subcutaneous fibromas in a dose-related manner. In mice, incidences of hepatocellular carcinomas were increased with feeding of AA, and 2-Me-l-NA increased the incidence of subcutaneous hemangiosarcomas. 1-Am-2-MeA did not appear to be carcinogenic in the mouse. Nephrotoxicity was associated with feeding of AA to female rats and 1-Am-2-MeA to mice. |
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Keywords: | AA, 2-aminoanthraquinone 1-Am-2-MeA, 1-amino-2-methylanthraquinone FBGN, foreign body granulomatous nephritis 2-Me-1-NA, 2-methyl-1-nitroanthraquinone |
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