Solution thermodynamics of some potentially long-acting norethinedrone derivatives III. Measurement of aqueous solubilities and the use of group free energy contributions in predicting partition coefficients |
| |
| Authors: | G.A. Lewis R.P. Enever |
| |
| Affiliation: | Department of Pharmaceutics, The School of Pharmacy, University of London, 29/39 Brunswick Square London WCIN 1AX England |
| |
| Abstract: | The solubilities in water of norethindrone and 7 of its derivatives have been measured and the results compared with the values predicted by a theory of additivity of group contributions to the free energy transfer of solutes between hydrocarbon and water. Since agreement between the two is reasonable, it was shown how the aqueous solubilities of very hydrophobic derivatives can be estimated where they are too low for measurement. |
| |
| Keywords: | To whom correspondence should be addressed. |
| 本文献已被 ScienceDirect 等数据库收录！ |
