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Effects of methylmercuric chloride on high affinity uptake of certain putative neurotransmitters in neuroblastoma and glioma cell cultures |
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| Authors: | K.N. Prasad M.E. Harrington S.C. Bondy |
| Affiliation: | 1. Departments of Radiology University of Colorado Medical Center,4200 East Ninth Avenue, Denver, CO 80262 U.S.A.;2. Department of Neurology, University of Colorado Medical Center, 4200 East Ninth Avenue, Denver, CO 80262 U.S.A.;3. National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709 U.S.A. |
| Abstract: | The effect of methylmercuric chloride (CH3HgCl) on high affinity uptake of certain putative neurotransmitters on mouse neuroblastoma (NBE?) and rat glioma (C-6) cells in culture 3 days after treatment was studied. The energydependent accumulation of radioactive choline was decreased in NB cells afte treatment with CH3HgCl (1 μm), whereas the accumulation of radioactive glycine or glutamate was increased. The uptake of radioactive glycine or glutamate in glioma cells was decreased after treatment with CH3HgCl (0.3 μM). High affinity uptake of choline was not demonstrable in glioma cells. Low concentrations of CH3HgCl affect the accumulation of glycine and glutamate in glioma and NB cells in an opposite manner. |
| Keywords: | GABA γ-aminobutyric acid NB neuroblastoma PBS Phosphate-buffered saline |
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