In vitro transformation of hamster embryo cells with a glutamic acid pyrolysis product |
| |
| Authors: | Takayama Shozo Hirakawa Tadashi Tanaka Machiko Kawachi Takashi Sugimura Takashi |
| |
| Affiliation: | 2. Department of Experimental Pathology, Cancer Institute, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan;1. Biochemistry Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104 Japan |
| |
| Abstract: | The in vitro activity of the glutamic acid pyrolysis product 2-amino-6-methyl-dipyrido[l,2-a:3',2'-d]imidazole (Glu-P-1) was examined in a transformation assay with cryopreserved hamster embryo cells. Glu-P-1 was cytotoxic at a concentration of 50 μg/ml, but induced morphological transformation of the cells at concentrations of 10 μg/ml and 20 μg/ml. Glu-P-1 may be carcinogenic for experimental animals. |
| |
| Keywords: | DMSO dimethylsulphoxide Glu-P-1, 2-amino-6-methyldipyrido [l,2-a:3',2'-d] imidazole Glu-P-2, 2-amino-dipyrido[1,2-a:3',2'-d]imidazole 3MC 3-methylcholanthrene |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
