Transmission of Y chromosomal microdeletions from father to son through intracytoplasmic sperm injection |
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| Authors: | S. Komori H. Kato S. Kobayashi K. Koyama S. Isojima |
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| Affiliation: | (1) Department of Obstetrics and Gynecology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8131, Japan Tel. +81-798-45-6481; Fax +81-798-46-4163 e-mail: komor615@hyo-med.ac.jp, JP;(2) Laboratory of Developmental Biology and Reproduction, Institute for Advanced Medical Sciences, Hyogo, Japan, JP;(3) Advanced Fertility Center, Huchu Hospital, Osaka, Japan, JP |
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| Abstract: | We conducted chromosomal analysis of three male infants fathered by severe oligozoospermic males with Y chromosomal microdeletions through intracytoplasmic sperm injection (ICSI). Two of the infants had the same Y chromosomal microdeletions as their fathers. The third infant also had a Y chromosomal microdeletion, which was longer than that found in his father. The results confirm that Y chromosomal microdeletions are transmitted from a father to a son via ICSI and also suggest that the microdeletions may be expanded during such transmission. Genetic counseling for infertile couples contemplating ICSI is important if the male carries Y chromosomal microdeletions. Received: January 11, 2002 / Accepted: May 19, 2002 |
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| Keywords: | Microdeletion Y chromosome Azoospermia Oligozoospermia ICSI |
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