Intragastric NaHCO3 perfusion and vagal-induced ulcer formation in the rat stomach. |
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| Authors: | C W Ogle C H Cho S Dai |
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| Affiliation: | Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong, China |
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| Abstract: | The effects of electrical vagal stimulation on gastric acid output and ulcer formation were studied in rats intragastrically perfused with saline or NaHCO3 solutions. Vagal stimulation produced a 100% incidence of glandular lesions and a significant increase in total acid output in saline-perfused stomachs. Antacid perfusion failed to prevent ulcer formation despite complete neutralization of the increased acid output. It is considered that vagal-induced gastric glandular lesions are not acid dependent. |
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| Keywords: | Vagus Gastric ulceration |
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