Clinical and haematological improvement induced by etidronate in a patient with idiopathic myelofibrosis and osteosclerosis |
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Authors: | Piera Sivera Luigi Cesano Angelo Guerrasio Clara Camaschella Umberto Mazza |
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Affiliation: | Dipartimento di Scienze Cliniche e Biologiche-Medicina Interna;Dipartimento di Scienze Biomediche e Oncologia Umana, Universita'di Torino, Italy |
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Abstract: | Summary We report a patient with agnogenic myeloid metaplasia associated with debilitating bone pain due to increased bone turnover and osteosclerosis. Treatment with etidronate at a dose of 6 mg/kg per day on alternate months resulted in a complete recovery of bone symptoms and normalization of metabolic parameters of bone turnover; unexpectedly, a sustained haematological improvement was also observed after several months of therapy, suggesting that bone marrow microenvironment improvement was able to restore a nearly normal haemopoiesis. We suggest that diphosphonate therapy may be of value in patients with AMM and increased bone turnover. |
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Keywords: | myelofibrosis osteosclerosis etidronate |
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