雷公藤中毒的大鼠实验病理研究

雷公藤误服中毒病例屡有报道,关于雷公藤中毒的病理研究尚少。本实验用常规光学显微镜、电镜和组织化学等方法,观察中毒大鼠主要脏器病变的分布和性质,探讨其中毒机理和临床病理的联系。材料和方法一、实验用药:用1982年2月湖北省通城县收

An Experimental Pathological Study of Acute Tripterygium wilfordii Intoxication in Rats

Acute intoxication was orally induced in rats with decoction of the bark derived from the raw roots of Tripterygium wilfordii Hook.f.in single and repeated lethal doses.Pathologic changes in the major organs of all sacrificed or dead rats were studied by light microscopy,electron microscopy and histochemical procedure. Relatively specific and constant pathologic changes following treatment were observed in the lymphoid organs, for example,the lymphocytes of the spleen,thymus and lymphonodi exhibited necrosis characterized by striking pyknosis and karyorrhexis and decrease in number.There were varying degrees of degeneration and necrosis in the parenchymatous cells of the heart,liver and kidney.Congestion,hemorrhage or necrosis were found in the mucous membranes of the gastrointestiual tract. The mechanism of the toxicological pathologicchanges and the relation between clinic and pathology were studied.On the basis of our present data,the decoction seems to possess cytotoxic action that is analogous to immunosuppressive agents.