| 人参皂甙和酮布芬对烟雾吸入性肺损伤的影响 |
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| 引用本文： | 黄钺华,张敏,王传年,李元平,史景泉,许平庆.人参皂甙和酮布芬对烟雾吸入性肺损伤的影响[J].第三军医大学学报,1988(6). |
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| 作者姓名： | 黄钺华 张敏 王传年 李元平 史景泉 许平庆 |
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| 作者单位： | 第三军医大学药理学教研室
(黄钺华，张敏，王传年)，第三军医大学病理解剖学教研室
(李元平，史景泉)，第三军医大学病理解剖学教研室(许平庆) |
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| 摘 要： | 家兔烟雾吸入伤后6h,肺血管通透性和循环中血小板聚集率均明显增加,气管和肺部也有明显病变。治疗组于伤后15min静注人参总皂甙或酮布芬后6h,虽然两种药物均使循环中血小板聚集率显著降低,但只有人参总皂甙能明显降低伤后增加的肺血管通透性和减轻气管和肺部的病变。大白鼠在类似的实验条件下,人参总皂甙给药后1h,可使血中PGI_2水平升高,TXA_2/PGI_2的比值明显下降。
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| 关 键 词： | 人参皂甙 酮布芬 烟雾吸入伤 肺血管通透性 血小板凝聚 |
Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats |
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| Huang Yuehua,et al.Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats[J].Acta Academiae Medicinae Militaris Tertiae,1988(6). |
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| Authors: | Huang Yuehua |
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| Abstract: | In the control rabbits 6 h after smoke inhalation injury, the pulmonary vascular permeability and the circulating platelet aggregation percentage increased distinctly, pathological changes of trachea and lung were marked. In the other 2 groups, ginsenosides (25 mg/kg, iv) or ketoprofen (12 mg/kg, iv) were given 15 min after injury, 6 h after treatment, although both drugs decreased, the aggregation percentage of circulating platelets, only ginsenosides did alleviate the augmented pulmonary vascular permeabil ity and the pathological changes of trachea and lung. In the similar model of smoke inhalation injury in rats, ginsensi-des increased the PGI2 level in arterial blood and reduced the ratio of TXA2/ PGI2 1 h after treatment. |
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| Keywords: | Ginsenosides Ketoprofen Smoke inhalation injury Pulmonary vascular permeability Platelets aggregation |
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