富硒麦芽对阿霉素致小鼠心脏毒性的保护作用

目的：探讨含硒制剂诱导金属硫蛋白在对抗阿霉素心脏毒性中的作用，比较无机硒制剂亚硒酸钠与有机硒制剂富硒麦芽。方法：不同时间给小鼠喂予硒制剂后取血分离血清，按常规查ＧＯＴ和ＣＫ活性，按ＤＴＮＢ法测ＧＳＨ－Ｐｘ活性；取心、肝、肾组织按Ｈｇ－Ｃｈｅｌｅｘ法测金属硫蛋白（）含量并做心脏病理学检查。结果：两种含硒制剂均能减轻阿霉素引起的体重下降，ＧＯＴ与ＣＫ酶升高及心脏病理损害，其中富硒麦芽的效果略优于亚硒酸

The protective action of Malt-Se to the cardiotoxicity of doxorubicin by Malt-Se

OBJECTIVE:To study the effect of MT during Na 2SeO 3 and MaltSe on the cardictoxicity produced by doxorubicin,and to compare organic and inorganic compounds containingSe.METHODS:The measurement of GOT and CK in blood serum and examination of the pathological heart damage was done with routine methods.The GSHPx activity in blood serum was assayed by DTNB method.Hgchelex method was used for determination of MT in heart,liver and kidney.RESULTS:Both of the compounds can resist the toxicities of doxorubicin,such as the body weight decreased,GOT and CK increased and pathological heart damage(P<0.01 or P<0.05).They also increase the activity of GSHPx(PP<0.01) and induce metallothionein(MT) in heart,liver and kidney(P<0.01 or P<0.05).The effects of using the compounds continuously is better than that of preadministration or retroadministration.CONCLUSION:Those suggeste that GSHPx and MT may all have the cardicprotective effects,and organic compound(Malt-Se) may be safer than inorganic one(Na 2SeO 3).