| 奎硫平治疗抑郁发作的对照研究 |
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| 引用本文： | 王瑛,侯明捷,范华,史晓宁,王传跃.奎硫平治疗抑郁发作的对照研究[J].临床精神医学杂志,2009,19(2). |
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| 作者姓名： | 王瑛 侯明捷 范华 史晓宁 王传跃 |
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| 作者单位： | 首都医科大学附属北京安定医院,100088 |
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| 摘 要： | 目的:探讨奎硫平对抑郁发作的疗效和安全性。方法:收集抑郁发作或复发性抑郁的患者60例,分为奎硫平组和5-羟色胺再摄取抑制剂(SSRIs)组各30例,疗程8周。使用Montgomery-As-berg抑郁量表(MADRS)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果:治疗8周两组MADRS、HAMD和HAMA量表减分值相仿(P均>0.05),治疗1周末奎硫平组即显示疗效优于SSRIs组(P均<0.05);奎硫平组MADRS量表失眠障碍因子减分值大。治疗8周奎硫平组有效率为25例(83.3%),SSRIs组为26例(86.7%)。奎硫平组无转躁患者,而SSRIs组转躁3例。奎硫平组头晕、口干、便秘的发生率明显多于SSRIs组。结论:奎硫平单药治疗抑郁发作的疗效与SSRIs相当,可改善患者失眠和焦虑症状,头晕、口干、便秘等不良反应较多见。
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| 关 键 词： | 奎硫平 抑郁发作 5-羟色胺再摄取抑制剂 |
A control study of quetiapine in the treatment of depression |
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| WANG Ying,HOU Ming-jie,FAN Hua,SHI Xiao-ning,WANG Chuan-yue.A control study of quetiapine in the treatment of depression[J].Journal of Clinical Psychological Medicine,2009,19(2). |
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| Authors: | WANG Ying HOU Ming-jie FAN Hua SHI Xiao-ning WANG Chuan-yue |
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| Institution: | WANG Ying,HOU Ming-jie,FAN Hua,SHI Xiao-ning,WANG Chuan-yue.Beijing ,ing Hospital Affiliated to Capital Medical University,Beijing 100088,China |
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| Abstract: | Objective:To detect the efficacy and safety of single quetiapine in the treatment of depression. Method:60 patients with depression or recurrent depression were assigned into quetiapine group and selective serotonin reuptake inhibitors(SSRIs)group.Course of treatment was 8 weeks.Montgomery-Asberg depressive scale(MADRS),Hamilton depressive scale(HAMD)and Hamilion anxiety scale(HAMA)were applied to evaluate efficacy,and treatment emergent symptoms scale(TESS)was applied to evaluate side-effect of drugs. Resu... |
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| Keywords: | quetipine depression SSRIs |
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