制霉素联合乳酸菌治疗妊娠期复发性外阴阴道念珠菌感染的临床疗效观察

目的 探讨制霉素泡腾片（商品名：米克定泡腾片）联合乳酸菌阴道胶囊治疗妊娠期复发性外阴阴道念珠菌感染的临床疗效。方法 选取2011年3月～2014年12月在笔者医院就诊的妊娠合并复发性外阴阴道念珠菌感染患者108例，按1∶ 1随机分为对照组和观察组，对照组采用米克定泡腾片治疗14天，观察组采用米克定泡腾片治疗14天后再用乳酸菌阴道胶囊治疗7天，停药7天后比较两组患者临床疗效及远期复发率。结果 观察组治疗有效率为92.59%（50/54），远高于对照组的70.37%（38/54），差异具有统计学意义（P<0.05），远期复发率观察为8.00%（4/50），低于对照组的26.32%（10/38），差异具有统计学意义（P<0.05）。结论 米克定泡腾片联合乳酸菌阴道胶囊治疗妊娠期合并复发性外阴阴道念珠菌感染疗效显著，不良反应小，复发率低。

Clinical Effects of Combination Use of Nystatin with Lactic Acid Bacteria on Recurrent Vulvovaginal Candidiasis during Pregnancy

Objective To evaluate the effects of combination use of nystatin with lactic acid bacteria on recurrent vulvovaginal candidiasis during pregnancy. Methods One hundred and eight outpatients with recurrent vulvovaginal candidiasis during pregnancy from march 2011 to December 2014 were recruited and divided into two group randomly. The patients in control group received Nystain Vaginal Effervescent tablets daily for 2 week.The patients in observation group received nystain vaginal effervescent tablets daily for 14 days,and then received lactic acid bacteria treatment for 7 days. Clinical effects were observed 7days after suspension of medication,and long-term effects were evaluated. Results The effective rate of observation group was 92.59%(50/54).The effective rate of control group was 70.37%(38/54). The effective rate of observation group was higher than that of control group,and there was significant different(P<0.05) between two groups. The recurrence rate of observation group was 8.00%(4/50).The recurrence rate of control group was 26.32%(10/38).The recurrence rate of observation group was lower than that of control group,and there was significant different(P<0.05) among two groups. Conclusion The clinical effects of combination use of nystain vaginal effervescent tablets with Lactic acid bacteria on recurrent vulvovaginal candidiasis during pregnancy are obvious with little side effects,and it can reduce the rate of recurrence of symptomatic vulvovaginal candidiasis.