Population studies of leukocyte-reactive antinuclear antibody and HLA antigens |
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Authors: | T. D. Kinsella J. Miller J. P. Gofton F. B. Vasey |
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Affiliation: | (1) Rheumatic Disease Units, University of Calgary, T2E OA1 Calgary, Alberta, Canada;(2) University of British Columbia, Vancouver, B. C., Canada;(3) Division of Rheumatology, University of South Florida, Tampa, Florida, USA |
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Abstract: | Summary The prevalence of serum leukocyte-reactive antinuclear antibody (LR-ANA) was determined in 31 patients with ankylosing spondylitis (AS), their age-and gender-matched normal controls, and two tribes of 340 West Coast Canadian Indians (Bella Coolas and Haidas). At a serum dilution of 1:10, the prevalence of LR-ANA in AS and controls was 45% and 7%, respectively. At 1:20 dilution, the prevalence was 23% in AS, 0% in controls, 29% in Bella Coolas and 27% in Haidas. No concordance was found among LR-ANA, HLA-B27 and CREG-B7, and nine HLA-A and seven HLA-B antigens in the Indian tribes. These studies confirm an increased prevalence of LR-ANA in AS and AS kindreds. but the latter association appears to be independent of HLA antigens. |
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Keywords: | Leukocyte-reactive ANA HLA Ankylosing spondylitis |
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