心力衰竭患者脑钠素水平与6 min步行试验相关性研究

目的探讨心力衰竭(心衰)患者血浆脑钠素(BNP)水平与6 min步行试验的相关性,进一步说明BNP测定对心衰的重要性.方法随机选择106例住院心衰患者及65例无器质性心脏病患者作为研究对象.入院当日采集血标本以备血浆BNP、血糖、血脂等检查,并于当日完成6 min步行试验.采用ELISA法测定血浆BNP水平.血浆BNP水平与6 min步行距离的相关性采用SPSS for Windows V10.0软件包分析.结果随着心衰程度的加重,血浆BNP水平逐渐升高,与6 min步行距离具有良好的相关性(r=-0.804,P＜0.01).结论血浆BNP水平可以判断心衰患者的严重程度,与6 min步行试验相比,具有更广泛的临床应用价值.

Correlation of brain natriuretic peptide level to 6-min walk test performance in patients with heart failure

Objective:To explore the correlation of brain natriuretic peptide level to 6-min walk test performance in patients with heart failure(HF) and to elucidate the importance of measurement of BNP to HF. Method:The 106 hospitalized cases with HF and 65 controls without HF were included in the study. Within 1 day blood samples of BNP, sugar and lipid were obtained, and the 6-min walk test were measured. The plasma levels of BNP were examined by ELISA. The correlation of plasma levels of BNP to the 6-min walk distance were analyzed by SPSS for Windows V10.0 statistic package. Result:The plasma levels of BNP were gradually elevated with the severity of HF. A significant correlation was observed between the BNP concentration and the distance walked (r=- 0.804,P< 0.01). Conclusion:The plasma levels of BNP maybe a judgement to assess the severity of HF and have wider application value compared to 6-min walk test.