依托咪酯静脉麻醉疗效观察

目的观察依托咪酯用于静脉维持麻醉的临床疗效。方法选择择期行2h之内手术病人100例,随机分为依托咪酯组（E组）和丙泊酚组（P组）,每组50例。2组病人麻醉诱导一致,E组采用依托咪酯维持剂量为7～15μg/（kg.min）,P组采用丙泊酚的维持剂量为60～160μg/（kg.min）。观察2组麻醉前、诱导后5、30、60min,拔管时心血管反应、苏醒的情况及术毕不良反应。结果P组病人诱导后30、60min平均动脉压（MAP）均低于麻醉前（P〈0.05）;E组血压较P组更为平稳（P〈0.05）;2组病人术毕苏醒时间及不良反应比较差异无统计学意义（P〉0.05）。结论依托咪酯用于静脉维持麻醉平稳,苏醒迅速。

Effect of Etomidate in Intravenous Anesthesia

Objective To evaluate the effect of etomidate in total intravenous anesthesia （TIVA）.Methods 100 patients scheduled for operation which time were no more than two hours were divided into two groups of 50 each：etomidate group（group E）arid propofol group（group P）.The two groups have the same anesthesia induction,The patients in group E was maintained with etomidate 7~15 μg/（kg·min）,and the patients in group P was maintained with propofol 60~160 μg/（kg·min）.Observed cardiovasecular efects,analepsia condition and the side effect before anesthesia,5,30,60 min after anesthesia and tracheal extubation.Results The MAP of 30,60 min after anesthesia in group P is lower than before anesthesia（P〈0.05）,Groups E have more stabilized hemodynamics than Groups P（P〈0.05）.The wake time of analepsia and side effects in group E is no longer than that in group P（P〉0.05）.Conclusions There are minimal effects on cardiovascular function and rapid analepsia by etomidate on intravenous anesthesia.